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Control and eradication |
Control |
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Choice of vaccine |
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Vaccines need to be:
The choice of the strain (or strains) to include in the vaccine depends on the antigenic similarity of the outbreak strain to suitable vaccine strains. Field isolates are compared with a range of vaccine strains of the appropriate serotype using the strain characterisation ELISA or cross neutralisation assays. Potential vaccine users should consult their National or International Reference Laboratory for FMD, or a reputable vaccine manufacturer, about the most appropriate strain to use for vaccination. Vaccine strains have been selected for their
For these reasons, it is usually better to use a proven vaccine strain than to attempt to adapt a local field isolate for vaccine production. Field isolates should periodically be sent to the National or International FMD Reference Laboratory for antigenic characterisation to check for the appearance of new antigenic variants. This is particularly relevant in situations where vaccines appear to give poor protection. |
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