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Production Flow Chart
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Post-inactivation concentration and purification by ultrafiltration (Strohmaier,
1967) or, more effectively precipitation with polyethylene glycol
(PEG) (Wagner et al., 1970)
or polyethylene oxide (Adamowicz
et al., 1974), can yield a final virus product with a concentration
factor of up to 1000-fold. Post-inactivation purification reduces the
non-viral protein component of the antigen harvest, which is important
in the reduction of hypersensitivity reactions in vaccinated animals.
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